＜Various medical applications of IR radiation for different cells and tissue tissues.＞
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| Medical application |
Target | Light source or material | Wavelengths | Results |
|---|---|---|---|---|
| 創傷治癒 | 皮膚の怪我（ラット） | セラミックコートシート | 5.6–25 μm (PEAK 8–12 μm) | 創傷治癒促進＋TGF-β1 の発現 |
| 創傷治癒 | 皮膚の擦り傷（マウス） | 半導体レーザー | 810 nm | コラーゲンの集積と創傷治癒効果の増大 |
| 創傷治癒 | 軟組織（ラット） | 半導体レーザー | 904 nm | 創傷治癒＋exclusion zone (EZ)の促進 ＋ (1H NMR 1/T2)の増大 |
| 創傷治癒 | 軟組織（ラット） | 半導体レーザー | 904 nm | 創傷治癒の促進 、膜組織効果の測定（by 1H NMR tau©） |
| 神経刺激 | 坐骨神経（ラット） | 自由電子レーザー | 2.1, 3.0, 4.0, 4.5, 5.0, and 6.1 μm | 坐骨神経の小束に於ける特定エリアでの反応が発生 |
| 神経刺激 | 心臓（成長したウサギ） | 半導体レーザー | 1.851 μm | 成長したウサギの心臓に於ける光学鼓動の発現 |
| 神経刺激 | スナネズミ聴覚神経 | YAG レーザー（ホルミウムをドープ） | 2.12 μm | 光照射は蝸牛の反応幅を刺激した |
| 神経刺激 | 坐骨神経（ラット） | 半導体レーザー | 1.875 μm | ハイブリッド（電気・光学）刺激は持続的な筋収縮を発生させ、レーザー出力の必要値を下げた |
| 神経刺激 | ||||
| 神経刺激 | ヒト胎児腎細胞293 | 半導体レーザー | 1.889 μm | 一過的な光学刺激に於いて膜組織の静電容量が変化した |
| 光老化 | 肌（人） | 同下 | 600–1500 nm | フリーラジカルの形成とβカロチンの成分（抗酸化物）を減少 |
| 光老化 | 真皮（人） | 放射経路に水フィルターを備えた赤外線A（IR-A）放射線源 | 760–1440 nm | 真皮に於ける MMP-1の発現が増加 |
| 腫瘍への効果 | ヘーラ子宮頚ガン細胞 | Waveguide Thermal Emitter | 3.6, 4.1 or 5.0 μm | ミトコンドリア細胞膜電位の崩壊を引き起こし、酸化ストレスを増加させた |
| 腫瘍 | 乳癌細胞＋健常胸上皮細胞 | Blackbody source equipped with 3–5 μm filter≒ 3–5 μm filter（セラミック） | 3–5 μm | Induced G2/M 癌細胞サイクルの停止を誘導し、マイクロチューブネットワークを再構成し、アクチン・フィラメント構造を変化させた |
| 腫瘍 | A549肺腺がん細胞 | 放射経路に水フィルターを備えたNIR放射線源 | 1.1–1.8 μm | DNA損傷時の反応経路を活性化した |
| 腫瘍 | ヒト細胞株(外陰部), ヒト肺癌株 (肺), 口腔の細胞 (舌),乳がん細胞株,歯肉腫 | FIR 発生パネルインキュベーター（炭素・シリカ・酸化アルミニウム・酸化チタン）にて被膜 | 4–20 μm (PEAK： 7 to 12 μm) | ATF3遺伝子の発現を高め、癌細胞の拡散を抑制した |
| 腫瘍 | 固形腫瘍 | 半導体レーザー | 904 nm | 88%の抗ガン作用（10年経過観察） |
| 腫瘍 | 固形腫瘍細胞形態学 | 半導体レーザー | 904 nm | 癌細胞患者に於いて選択的アポトーシス・壊死が発生 |
| 腫瘍 | 固形腫瘍：T2wMRI-Microdensitometry | 半導体レーザー | 904 nm | 癌患者に於ける抗腫瘍反応断定的なものとしての臨界面に於けるexclusion zone (EZ)の証拠となった |
| 腫瘍 | 固形腫瘍：serum levels of cytokines of peripheral leucocyte subsets | 半導体レーザー | 904 nm | 癌患者の細胞壊死因子及びTNF-α 可溶性IL-2レセプターに於ける免疫調整＋and CD4 + CD45RA+ and CD25+ activated |
| 脳神経再生 | 軽脳挫傷 | 近赤外線LED | 870 nm | 認識機能,睡眠、外傷後ストレス性障害の向上 |
| 脳神経再生 | 脳卒中（塞栓形成うさぎ） | レーザー | 808 nm | 大脳皮質に於けるATP量の増加 |
| 脳神経再生 | 人脂肪幹細胞 | 半導体レーザー | 810 nm, 980nm | 増殖と分化を刺激した |
＜Various medical applications of IR radiation for different cells and tissue tissues._1＞
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| Medical application |
Author, reference, et al | Year | Target | IR | Results |
|---|---|---|---|---|---|
| Wound healing | Toyokawa | 2003 | Skin wound in rat | Mid | Promoted wound healing and expression of TGF-β1 |
| Wound healing | Gupta | 2014 | Dermal abrasions in mice | Near | Enhanced collagen accumulation and healing effects |
| Wound healing | Santana-Blank | 2000, 2013 | Soft tissues in rat | Near | Promotes wound healing and exclusion zone (EZ) growth (1H NMR 1/T2) |
| Wound healing | Santana-Blank Rodríguez-Santana | 2013 2003 | Soft tissues in rat | Near | Promotes wound healing, membrane effect measured by 1H NMR tau© |
| Neural stimulation | Wells | 2005 | Rat sciatic nerve | Mid | Generated a spatially selective response in small fascicles of the sciatic nerve |
| Neural stimulation | Jenkins | 2013 | Adult rabbit heart | Near | Induced optical pacing of the adult rabbit heart |
| Neural stimulation | Izzo | 2006 | Gerbils auditory nerve | Near | Optical radiation stimulated the cochlear response amplitudes |
| Neural stimulation | Duke | 2012 | Rat sciatic nerve | Near | Hybrid electro-optical stimulation generated sustained muscle contractions and reduced the laser power requirements |
| Neural stimulation | Shapiro | 2012 | HEK-293T cells | Near | Altered the membrane electrical capacitance during optical stimulation transiently |
| Photoaging | Darvin | 2006 | Human skin | Near | Formed free radicals and decreased content of β–carotene antioxidants |
| Photoaging | Schroeder | 2008 | Human dermal fibroblasts | Near | Increased expression of MMP-1 in the dermis |
| Antitumor action | Tsai | 2016 | HeLa cervical cancer cell | Mid | Caused a collapse of mitochondrial membrane potential and an increase in oxidative stress. |
| Antitumor action | Chang | 2013 | Breast cancer cells and normal breast epithelial cells. | Mid | Induced G2/M cancer cell cycle arrest, remodeled the microtubule network and altered the actin filament formation |
| Antitumor action | Tanaka | 2012 | A549 lung adenocarcinoma cells | Near | Activated the DNA damage response pathway |
| Antitumor action | Yamashita | 2010 | A431 (vulva), A549 (lung), HSC3 (tongue), MCF7 (breast) and Sa3 (gingiva) cancer cells | Mid | Suppressed the proliferation of cancer cells through enhancing the expression of ATF3 gene |
| Antitumor action | Santana-Blank | 2002 | Solid tumor Clinical trial | Near | 88% anticancer effect. Ten years follow up |
| Antitumor action | Santana-Blank | 2002 | Solid tumor cytomorphology | Near | Selective apoptosis, necrosis, anoikis in tumor tissues of cancer patients |
| Antitumor action | Santana-Blank | 2013 | Solid tumor T2wMRI-Microdensitometry | Near | Evidence of interfacial water exclusion zone (EZ) as a predicator of anti-tumor response in cancer patients |
| Antitumor action | Santana-Blank | 1992 | Solid tumor serum levels of cytokines of peripheral leucocyte subsets | Near | Immuno-modulation in cancer patients of TNF-α sIL-2R and CD4 + CD45RA+ and CD25+ activated |
| Brain neural regeneration | Naeser | 2014 | Mild traumatic brain injury | Near | Improved cognitive function, sleep and post-traumatic stress disorder symptoms |
| Brain neural regeneration | Lapchak | 2010 | Strokes in embolized rabbits | Near | Increased cortical ATP content |
| Adipose regeneration | Wang, Y., | 2016 | human adipose-derived stem cells | Near | Stimulate the proliferation and differentiation |
＜Various medical applications of IR radiation for different cells and tissue tissues._2＞＜IR=LLLT(Razor)＞
2007
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| Author, reference, et al | Year | Target | Results |
|---|---|---|---|
| Lubert | 1992 | Fibroblasts | Prevent cell apoptosis and improve cell proliferation, migration and adhesion |
| Yu | 1994 | Fibroblasts | Prevent cell apoptosis and improve cell proliferation, migration and adhesion |
| Yu | 1997 | Skin wound | Prevent cell apoptosis and improve cell proliferation, migration and adhesion |
| Grossman | 1998 | Keratinocytes | Prevent cell apoptosis and improve cell proliferation, migration and adhesion |
| Moore | 2005 | Endothelial cells | Prevent cell apoptosis and improve cell proliferation, migration and adhesion |
| Agaiby | 2000 | Lymphocytes | Prevent cell apoptosis and improve cell proliferation, migration and adhesion |
| Crysler | 2003 | Human gingival fibroblasts | Prevent cell apoptosis and improve cell proliferation, migration and adhesion |
| Gavish: | 2006 | Porcine aortic smooth muscle cells | Modulated matrix metalloproteinase activity and gene expression |
| Shefer | Muscle satellite cells | Activate muscle satellite cells, enhancing their proliferation, inhibiting differentiation and regulating protein synthesis | |
| Hopkins | 2004 | Angiogenesis | Enhance neovascularisation, promote angiogenesis and increase collagen synthesis to promote healing of acute |
| Corazza | Wound rats | Acceleration of cutaneous wound heaing with a biphasic dose response | |
| Gigo | 2004 | Nerves | Stimulate healing |
| Results | 2005 | Tendons | Stimulate healing |
| Morrone | 2000 | Cartilage | Stimulate healing |
| Weber | 2006 | Bones | Stimulate healing |
| Shao | 2005 | Internal organs | Stimulate healing |
| Bjodal | 2006 | Pain, inflammation by injuries | Reduce |
| Carati | 2003 | Swelling | Reduce |
| Oron | 2001 | Injury or ischemia in skeletal and heart muscles | Beneficial（multiple animal models：in vivo） |
| Lapchak | 2008 | Damage after strokes | Mitigate damage in both animals and humans |
| Oron | 2007 | After traumatic brain injury | Mitigate damage in both animals and humans |
| Wu | 2009 | After spinal cord injury | Mitigate damage in both animals and humans |