References

< Various medical applications of IR radiation for different cells and tissue tissues._1 >

Medical application	Author, reference, et al	Year	Target	IR	Results
Wound healing	Toyokawa	2003	Skin wound in rat	Mid	Promoted wound healing and expression of TGF-β1
Wound healing	Gupta	2014	Dermal abrasions in mice	Near	Enhanced collagen accumulation and healing effects
Wound healing	Santana-Blank	2000, 2013	Soft tissues in rat	Near	Promotes wound healing and exclusion zone (EZ) growth (1H NMR 1/T2)
Wound healing	Santana-Blank Rodríguez-Santana	2013 2003	Soft tissues in rat	Near	Promotes wound healing, membrane effect measured by 1H NMR tau©
Neural stimulation	Wells	2005	Rat sciatic nerve	Mid	Generated a spatially selective response in small fascicles of the sciatic nerve
Neural stimulation	Jenkins	2013	Adult rabbit heart	Near	Induced optical pacing of the adult rabbit heart
Neural stimulation	Izzo	2006	Gerbils auditory nerve	Near	Optical radiation stimulated the cochlear response amplitudes
Neural stimulation	Duke	2012	Rat sciatic nerve	Near	Hybrid electro-optical stimulation generated sustained muscle contractions and reduced the laser power requirements
Neural stimulation	Shapiro	2012	HEK-293T cells	Near	Altered the membrane electrical capacitance during optical stimulation transiently
Photoaging	Darvin	2006	Human skin	Near	Formed free radicals and decreased content of β–carotene antioxidants
Photoaging	Schroeder	2008	Human dermal fibroblasts	Near	Increased expression of MMP-1 in the dermis
Antitumor action	Tsai	2016	HeLa cervical cancer cell	Mid	Caused a collapse of mitochondrial membrane potential and an increase in oxidative stress.
Antitumor action	Chang	2013	Breast cancer cells and normal breast epithelial cells.	Mid	Induced G2/M cancer cell cycle arrest, remodeled the microtubule network and altered the actin filament formation
Antitumor action	Tanaka	2012	A549 lung adenocarcinoma cells	Near	Activated the DNA damage response pathway
Antitumor action	Yamashita	2010	A431 (vulva), A549 (lung), HSC3 (tongue), MCF7 (breast) and Sa3 (gingiva) cancer cells	Mid	Suppressed the proliferation of cancer cells through enhancing the expression of ATF3 gene
Antitumor action	Santana-Blank	2002	Solid tumor Clinical trial	Near	88% anticancer effect. Ten years follow up
Antitumor action	Santana-Blank	2002	Solid tumor cytomorphology	Near	Selective apoptosis, necrosis, anoikis in tumor tissues of cancer patients
Antitumor action	Santana-Blank	2013	Solid tumor T2wMRI-Microdensitometry	Near	Evidence of interfacial water exclusion zone (EZ) as a predicator of anti-tumor response in cancer patients
Antitumor action	Santana-Blank	1992	Solid tumor serum levels of cytokines of peripheral leucocyte subsets	Near	Immuno-modulation in cancer patients of TNF-α sIL-2R and CD4 + CD45RA+ and CD25+ activated
Brain neural regeneration	Naeser	2014	Mild traumatic brain injury	Near	Improved cognitive function, sleep and post-traumatic stress disorder symptoms
Brain neural regeneration	Lapchak	2010	Strokes in embolized rabbits	Near	Increased cortical ATP content
Adipose regeneration	Wang, Y.,	2016	human adipose-derived stem cells	Near	Stimulate the proliferation and differentiation

< Various medical applications of IR radiation for different cells and tissue tissues._2 >
< IR=LLLT(Razor) >

2007

Author, reference, et al	Year	Target	Results
Lubert	1992	Fibroblasts	Prevent cell apoptosis and improve cell proliferation, migration and adhesion
Yu	1994	Fibroblasts	Prevent cell apoptosis and improve cell proliferation, migration and adhesion
Yu	1997	Skin wound	Prevent cell apoptosis and improve cell proliferation, migration and adhesion
Grossman	1998	Keratinocytes	Prevent cell apoptosis and improve cell proliferation, migration and adhesion
Moore	2005	Endothelial cells	Prevent cell apoptosis and improve cell proliferation, migration and adhesion
Agaiby	2000	Lymphocytes	Prevent cell apoptosis and improve cell proliferation, migration and adhesion
Crysler	2003	Human gingival fibroblasts	Prevent cell apoptosis and improve cell proliferation, migration and adhesion
Gavish:	2006	Porcine aortic smooth muscle cells	Modulated matrix metalloproteinase activity and gene expression
Shefer		Muscle satellite cells	Activate muscle satellite cells, enhancing their proliferation, inhibiting differentiation and regulating protein synthesis
Hopkins	2004	Angiogenesis	Enhance neovascularisation, promote angiogenesis and increase collagen synthesis to promote healing of acute
Corazza		Wound rats	Acceleration of cutaneous wound heaing with a biphasic dose response
Gigo	2004	Nerves	Stimulate healing
Results	2005	Tendons	Stimulate healing
Morrone	2000	Cartilage	Stimulate healing
Weber	2006	Bones	Stimulate healing
Shao	2005	Internal organs	Stimulate healing
Bjodal	2006	Pain, inflammation by injuries	Reduce
Carati	2003	Swelling	Reduce
Oron	2001	Injury or ischemia in skeletal and heart muscles	Beneficial（multiple animal models：in vivo）
Lapchak	2008	Damage after strokes	Mitigate damage in both animals and humans
Oron	2007	After traumatic brain injury	Mitigate damage in both animals and humans
Wu	2009	After spinal cord injury	Mitigate damage in both animals and humans